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Staphylococcus lugdunensis--a potential pathogen in oral infection
1Department of Oral Biochemistry, Seoul National University, Republic of Korea.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|September 30, 1999
Summary
Staphylococcus lugdunensis, a bacterium found in oral infections, demonstrates antibiotic resistance and virulence factors. This suggests its potential role as a pathogen in acute oral infections.
Area of Science:
- Oral Microbiology
- Infectious Diseases
- Bacterial Pathogenesis
Background:
- Staphylococcus lugdunensis is a coagulase-negative staphylococci species.
- Its role in oral infections is not well-established.
Purpose of the Study:
- To investigate the pathogenicity of Staphylococcus lugdunensis in acute oral infections.
Main Methods:
- Isolation of S. lugdunensis from patients with oral infections and healthy controls.
- Assessment of antibiotic susceptibility, in vitro cellular toxicity, in vivo virulence, and hemolytic activity.
- Dot blot analysis for delta-hemolysin gene detection.
Main Results:
- S. lugdunensis strains exhibited resistance to multiple antibiotics, including penicillin, ampicillin, methicillin, cephalothin, and clindamycin.
- The isolates displayed in vivo virulence and delta-like hemolysin activity, with synergistic hemolysis observed in four strains.
- Dot blot analysis confirmed the presence of the delta-hemolysin gene.
Conclusions:
- S. lugdunensis possesses virulence factors and antibiotic resistance relevant to oral infections.
- The findings suggest S. lugdunensis is a potential pathogen in acute oral infections.