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Updated: Aug 8, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
P53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations
J T Castle1, M Cardinali, F J Kratochvil
1Department of Oral Pathology, National Naval Dental Center, Bethesda, MD, USA. castle@afip.osd.mil
Objective:
Recent epidemiologic studies have identified a trend of increasing cancer incidence in younger patients. The purpose of this study was to determine whether this might be reflected by different molecular mechanisms for tumor development.
Study Design:
Dysplastic and malignant oral lesions from age-distinct patient populations were immunohistochemically analyzed for expression of p53 and cyclin D1. Chi-square analysis was used to determine statistical significance.
Results:
Eighty-two percent of "older" and 75% of "younger" carcinomas stained positively with p53; 63% of carcinomas in the older population and 55% of carcinomas in the younger population showed cyclin D1 positivity. Dysplasias showed similar cyclin D1 staining in both groups. Interestingly, 100% of "younger" dysplasias stained positively for p53, whereas 35.3% of "older" dysplastic lesions showed immunoreactivity. Staining of carcinomas was not statistically significant, whereas p53 staining of dysplasias proved highly significant (P < .025).
Conclusions:
p53 immunoreactivity is detectable at an earlier stage of carcinogenesis in younger patients than in the traditional risk population for oral cancer.
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