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Heterocyclic amine formation and the impact of structure on their mutagenicity
J S Felton1, M G Knize, F T Hatch
1Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, University of California, Livermore 94551, USA. felton1@ilnl.gov
Cancer Letters
|September 30, 1999
Abstract:
The occurrence and formation of heterocyclic amines in foods is discussed in light of the consistent finding of a new class of imidazopyridines. In addition, a quantitative structure-activity relationship will be presented correlating the potency of these imidazopyridines to predicted chemical properties. Although no strong linear correlation is found between the potency and the chemical properties, a low dipole moment is found to be a qualitative predictor of high mutagenic potency.