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Phytomedicine research in Germany.

H Wagner1

  • 1Centre of Pharma Research, Pharmaceutical Biology, University of Munich, Germany. H.Wagner@cup.uni-muenchen.de

Environmental Health Perspectives
|September 30, 1999
PubMed
Summary

Standardized herbal medicines, including Crataegus and Ginkgo, show therapeutic equivalence to conventional drugs without adverse effects. Their polyvalent action is being investigated at the molecular level.

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Area of Science:

  • Phytopharmaceuticals and their clinical applications.
  • Pharmacology of herbal medicine.
  • Molecular mechanisms of drug action.

Background:

  • Germany has conducted over 300 clinical studies on standardized phytopharmaceuticals since 1980.
  • Herbal drugs investigated include Crataegus, Silybum, Ginkgo, Hypericum, and others.
  • These studies focused on treating moderate diseases and prevention.

Purpose of the Study:

  • To assess the efficacy of standardized phytopharmaceuticals.
  • To compare their therapeutic equivalence and safety with conventional chemotherapeutics.
  • To investigate the unique mechanisms of action of herbal preparations.

Main Methods:

  • Clinical trials and comparative studies.
  • Assessment of therapeutic equivalence.
  • Investigation of phytopharmaceutical efficacy and safety profiles.

Main Results:

  • Phytopharmaceuticals demonstrated full therapeutic equivalence to chemotherapeutics.
  • These herbal medicines were found to be devoid of adverse effects.
  • Their mechanism of action is characterized as polyvalent, acting additively or potentiating.

Conclusions:

  • Standardized phytopharmaceuticals offer a safe and effective alternative for treating moderate diseases.
  • The polyvalent action of herbal drugs presents a distinct pharmacological approach.
  • Further research is ongoing to elucidate the molecular basis of their long-term effects and low-dose efficacy.

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