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Transgenic rabbit models for biomedical research: current status, basic methods and future perspectives.

J Fan1, M Challah, T Watanabe

  • 1Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Japan. j-fan@md.tsukuba.ac.jp

Pathology International
|October 3, 1999
PubMed
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Genetically modified rabbits, created using recombinant DNA technology, serve as valuable models for human diseases and efficient producers of therapeutic proteins, advancing biomedical research and biotechnology.

Area of Science:

  • Biotechnology and Genetic Engineering
  • Animal Models in Research
  • Molecular Biology

Background:

  • Recombinant DNA technology has enabled the creation of genetically modified animals.
  • Transgenic rabbits have emerged as significant models over the past decade.
  • Advancements in gene targeting and cloning facilitate transgenic rabbit production.

Purpose of the Study:

  • To review progress in the development of transgenic rabbits.
  • To highlight applications of transgenic rabbits as human disease models.
  • To discuss their use in producing therapeutic proteins.

Main Methods:

  • Review of scientific literature on transgenic rabbit technology.
  • Analysis of gene targeting and animal cloning techniques.

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  • Evaluation of applications in disease modeling and bioproduction.

    • Main Results:

    • Transgenic rabbits offer a large mammal model for studying human diseases.
    • They provide a viable system for bioproduction of foreign proteins.
    • Progress in gene targeting and cloning enhances their utility.

    Conclusions:

    • Transgenic rabbits are crucial tools in biomedical research.
    • They hold significant potential for therapeutic protein production.
    • Continued advancements will expand their applications in science and industry.