Transgenic rabbit models for biomedical research: current status, basic methods and future perspectives

Area of Science:

• Biotechnology and Genetic Engineering
• Animal Models in Research
• Molecular Biology

Background:

• Recombinant DNA technology has enabled the creation of genetically modified animals.
• Transgenic rabbits have emerged as significant models over the past decade.
• Advancements in gene targeting and cloning facilitate transgenic rabbit production.

Purpose of the Study:

• To review progress in the development of transgenic rabbits.
• To highlight applications of transgenic rabbits as human disease models.
• To discuss their use in producing therapeutic proteins.

Main Methods:

• Review of scientific literature on transgenic rabbit technology.
• Analysis of gene targeting and animal cloning techniques.
• Evaluation of applications in disease modeling and bioproduction.

Main Results:

• Transgenic rabbits offer a large mammal model for studying human diseases.
• They provide a viable system for bioproduction of foreign proteins.
• Progress in gene targeting and cloning enhances their utility.

Conclusions:

• Transgenic rabbits are crucial tools in biomedical research.
• They hold significant potential for therapeutic protein production.
• Continued advancements will expand their applications in science and industry.