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Steroid-responsive cochlear dysfunction in the MRL/lpr autoimmune mouse.

R J Wobig1, J b Kempton, D R Trune

  • 1Department of Otolaryngology-Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health Sciences University, Portland, 97201-3098, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 3, 1999
PubMed
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Prednisolone improved and stabilized auditory thresholds in mice with autoimmune hearing loss. This autoimmune mouse model shows promise for studying steroid mechanisms in cochlear disorders.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pharmacology

Background:

  • Corticosteroids are used for autoimmune sensorineural hearing loss, but their mechanism in the inner ear is unclear.
  • The MRL/lpr mouse is a model for autoimmune diseases, including sensorineural hearing loss.

Purpose of the Study:

  • To investigate the effects of prednisolone on auditory function in the MRL/lpr mouse model.
  • To evaluate the MRL/lpr mouse as a model for studying steroid mechanisms in autoimmune hearing loss.

Main Methods:

  • Administered prednisolone to MRL/lpr mice before and after the onset of hearing loss.
  • Measured auditory brainstem response thresholds and serum immune complexes.
  • Monitored survival rates.

Main Results:

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  • Prednisolone treatment significantly improved and stabilized auditory thresholds in affected mice.
  • Early prednisolone treatment reduced immune complexes, increased survival, and maintained lower auditory thresholds.
  • Untreated controls showed worsening auditory thresholds.

Conclusions:

  • The MRL/lpr mouse model is suitable for studying steroid-responsive mechanisms in autoimmune sensorineural hearing loss.
  • Prednisolone demonstrates therapeutic potential in this autoimmune hearing loss model.
  • Findings support further research into steroid therapy for various hearing disorders.