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Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...

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[Plasma concentration of biochemical markers in pre-eclampsia-eclampsia and its association with the severity of the disease].

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Disturbing the light-darkness pattern reduces circulating testosterone in healthy men.

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Related Experiment Video

Updated: Jul 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

[The process of cell degeneration].

V Cortés-Gallegos, I Sojo Aranda

    Ginecologia Y Obstetricia De Mexico
    |October 3, 1999
    PubMed
    Summary

    This study explores non-classical methods to maintain the well-being of healthy women, aiming to delay cellular degeneration before menopause. It addresses public health challenges and societal shifts women experience during this life stage.

    Area of Science:

    • Gerontology
    • Women's Health
    • Cellular Biology

    Context:

    • Societal and biological changes during pre-menopause.
    • The need for proactive health strategies for women.
    • Advancements in biomedical technology and public health.

    Purpose:

    • To explore non-classical approaches for maintaining women's well-being.
    • To address cellular degenerative processes before menopause.
    • To inform public health strategies for an aging female population.

    Summary:

    • Investigates peripheral and local phenomena related to women's health.
    • Proposes methods to defer degenerative cellular processes in healthy women.
    • Highlights the transition women undergo from reproductive to productive societal roles.

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    Impact:

    • Aims to improve the quality of life for women approaching menopause.
    • Contributes to understanding and managing public health issues in women.
    • Provides insights into proactive health maintenance for a growing demographic.