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[Thromboembolic diseases in children]
1Barneklinikken Rikshospitalet, Oslo.
Insights
Pediatric thromboembolic disease is rising, yet treatment guidelines lack evidence. This review outlines current concepts and suggests applying adult treatment principles to children for better outcomes.
Area of Science:
- Pediatric Hematology
- Thromboembolic Diseases
- Intensive Care Medicine
Context:
- Increasing incidence of thromboembolic diseases in children.
- Limited scientific evidence for pediatric treatment guidelines.
- Reliance on adult medicine extrapolations and expert opinions.
Purpose:
- To present current concepts of pediatric thromboembolic diseases.
- To outline characteristic features and differences from adult disease.
- To provide guidelines for antithrombotic treatment in children.
Summary:
- Reviews literature on pediatric thromboembolic diseases, highlighting unique features.
- Discusses challenges due to lack of specific pediatric evidence.
- Offers guidelines for antithrombotic therapy and thrombophilia screening.
Impact:
- Aims to improve clinical management of pediatric thromboembolic events.
- Advocates for wider screening of thrombophilic disorders in children.
- Promotes the application of modern adult treatment principles in pediatric care.
Abstract:
The incidence of thromboembolic diseases in children is increasing, probably as a consequence of medical progress and modern intensive care. Due to lack of scientific evidence, clinical recommendations for treatment of children are mainly based on opinions and extrapolations from adult medicine. This article presents current concepts of thromboembolic diseases in children, based on a review of the literature. Characteristic features are presented and differences between the disease in adults and children are outlined. Guidelines for antithrombotic treatment are provided. We suggest that screening for thrombophilic disorders should be performed on wide indications, and that modern principles of treatment in adult medicine should also be applied for children with thromboembolic diseases.
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