Inflammatory responses to amyloid fibrils
Related Experiment Video
Updated: Jul 21, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 6, 2013
S L Yates1, J Kocsis-Angle, P Embury
1Gliatech Inc., Cleveland, Ohio 44122, USA.
Abstract:
Our laboratory has routinely used the methodologies described here to characterize the effects of fibrillar A beta and amylin on cytokine synthesis and secretion by LPS-differentiated THP-1 cells. Because LPS-treated THP-1 cells resemble macrophage and microglia, this assay system represents an in vitro model of the potential interactions between A beta-containing senile plaques and microglia in the AD brain. As such, these methodologies should prove useful in the identification of compounds that inhibit this A beta-induced inflammatory response.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Clot Retraction and Fibrinolysis
Amebiasis
Chronic Inflammation: Introduction

