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Association of prenatal and perinatal complications with subsequent bipolar disorder and schizophrenia

S L Buka1, A P Fan

  • 1Department of Maternal and Child Health, Harvard School of Public Health, Boston, MA 02115, USA. sbuka@hsph.harvard.edu

Schizophrenia Research
|October 3, 1999
PubMed

Insights

Prenatal and perinatal complications (PPCs) are linked to an increased risk of developing bipolar disorder. Further research is needed to explore genetic and gender factors in this association.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Epidemiology

Background:

  • Prenatal and perinatal complications (PPCs) are known risk factors for schizophrenia.
  • The association between PPCs and bipolar disorder requires further investigation.

Purpose of the Study:

  • To systematically review literature on the association between PPCs and bipolar disorder.
  • To analyze the strength of evidence for PPCs as a risk factor for bipolar disorder.

Main Methods:

  • Systematic literature review of studies published after 1965.
  • Analysis of odds ratios and prevalence of PPCs in bipolar disorder samples.

Main Results:

  • Three of four comparative studies showed a positive association between PPCs and bipolar disorder (odds ratios 1.0–12.0).
  • Prevalence of PPCs in bipolar samples without controls varied widely (3.8%–50.0%).

Conclusions:

  • PPCs may be associated with an increased risk of bipolar disorder.
  • Further research into genetic interactions, gender differences, and effect specificity is warranted for non-schizophrenia mental disorders.

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