Some fairly obvious distinctions between schizophrenia and bipolar disorder
Related Experiment Video
Updated: Oct 19, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
1Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA. GoldberT@INTRA.NIMH.nih.gov
Abstract:
In examining the ratio of 'famous' individuals with bipolar disorder to those with schizophrenia, it is evident that the ratio greatly favors those with bipolar disorder, suggesting that schizophrenia somehow precludes expert performance or high-level accomplishment. Why might this be so? One possible explanation lies in neurocognitive findings. In this review, I suggest that patients with schizophrenia perform consistently worse than patients with bipolar disorder on a variety of higher level cognitive tasks (though bipolar patients themselves often evince impairment in comparison to healthy controls). Working memory, in particular, appears to discriminate between the groups. However, questions remain, including the effects of state and medications, and the conclusion that I reach does not exclude the possibility that the two disorders share some but not all etiologic or pathophysiologic features.
Related Concept Videos
Bipolar Disorder
Schizophrenia
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Personality Disorders: Schizotypal and Histrionic
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...