Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood pool contrast agents for cardiovascular MR imaging.

L J Kroft1, A de Roos

  • 1Department of Radiology, C2-S, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Journal of Magnetic Resonance Imaging : JMRI
|October 3, 1999
PubMed
Summary

Blood pool contrast agents (BPCAs) enhance magnetic resonance angiography (MRA) by improving signal-to-noise ratio and resolution. Their use in myocardial perfusion requires fast injection, with safety considerations for human application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid function and IVF outcome for different indications of subfertility.

Reproduction & fertility·2022
Same author

Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: The NEO study.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2017
Same author

Coronary or thoracic artery calcium score in provoked and unprovoked pulmonary embolism: a case-control study.

Journal of thrombosis and haemostasis : JTH·2016
Same author

An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2016
Same author

Cardiovascular flexibility in middle-aged overweight South Asians vs. white Caucasians: response to short-term caloric restriction.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2015
Same author

Arrhythmogenic right ventricular dysplasia/cardiomyopathy: new avenues for diagnosis and treatment.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015

Area of Science:

  • Medical Imaging
  • Radiology
  • Cardiovascular Imaging

Background:

  • Contrast agent properties, particularly size, dictate distribution and elimination.
  • Blood pool contrast agents (BPCAs) offer potential for quantitative myocardial perfusion evaluation.
  • Fast contrast bolus injection is crucial for accurate perfusion assessment.

Purpose of the Study:

  • To explore the benefits of BPCAs in magnetic resonance angiography (MRA).
  • To evaluate the potential of BPCAs for quantitative myocardial perfusion imaging.
  • To discuss the implications of BPCA properties for imaging acquisition.

Main Methods:

  • Utilizing blood pool contrast agents (BPCAs) for first-pass perfusion studies.
  • Employing rapid injection techniques for contrast bolus delivery.

Related Experiment Videos

  • Investigating the impact of persistent signal enhancement on MRA acquisition parameters.

    • Main Results:

    • BPCAs enable longer acquisition windows, enhancing signal-to-noise ratio and image resolution in MRA.
    • High-resolution coronary imaging is significantly improved.
    • Multiple scans post-injection are feasible due to extended signal effects.
    • Ultrasmall paramagnetic iron oxide particles (USPIOs) show limitations in MRA due to T2* effects at higher doses.

    Conclusions:

    • BPCAs hold significant promise for advancing MRA, particularly for coronary imaging.
    • Quantitative myocardial perfusion imaging may be achievable with BPCAs and fast injection.
    • Safety considerations, including injection speed-related toxicity, require careful evaluation before human application.