Related Experiment Videos
Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid
1Lehrstuhl für Organische Chemie I der Universität, Universitätsstrasse 150, D-44780 Bochum (Germany).
Angewandte Chemie (International Ed. in English)
|October 3, 1999
Abstract:
It works even without the enzyme: The formation of the bioactive form 1 of isoniazid inside Mycobacterium tuberculosis does not depend on specific interactions within the active site of the inhibited enzyme, but rather relies on the fast addition of acyl radicals to electron-deficient heterocycles such as NAD(+).