Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wnt signalling shows its versatility.

A Bejsovec1

  • 1Northwestern University Department of Biochemistry, Molecular Biology and Cell Biology 2153 Sheridan Road, Evanston, Illinois 60208, USA. bejsovec@nwu.edu

Current Biology : CB
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flying at the head of the pack: Wnt biology in Drosophila.

Oncogene·2006
Same author

Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.

Nature cell biology·2001
Same author

Wnt signaling: an embarrassment of receptors.

Current biology : CB·2001
Same author

Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction.

Current biology : CB·2000
Same author

Production of transgenic Drosophila.

Methods in molecular biology (Clifton, N.J.)·2000
Same author

Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.

The Journal of cell biology·1999
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Wnt signaling regulates cell fate decisions across many animal species. Regulatory interactions within the pathway allow it to produce diverse outcomes depending on the biological context.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • Wnt signaling is a crucial pathway regulating cell fate determination in numerous animal species.
  • The pathway's diverse roles suggest context-dependent regulation.
  • Understanding these regulatory mechanisms is key to comprehending developmental processes.

Purpose of the Study:

  • To explore how regulatory interactions within the Wnt signaling pathway influence its diverse outcomes.
  • To elucidate the mechanisms by which Wnt signaling achieves context-specific effects on cell fate choices.

Main Methods:

  • Review of recent studies on Wnt signaling pathway regulation.
  • Analysis of molecular and genetic interactions affecting Wnt pathway activity.
  • Comparative analysis of Wnt pathway function in different developmental contexts.

Related Experiment Videos

Main Results:

  • Identified multiple regulatory points within the Wnt pathway.
  • Demonstrated that modifications at these regulatory steps alter pathway outcomes.
  • Showcased how the same pathway can yield different cell fate decisions based on regulatory inputs.

Conclusions:

  • Regulatory interactions are critical for modulating Wnt signaling outcomes.
  • The context-dependent nature of Wnt signaling arises from intricate regulatory networks.
  • This regulatory flexibility explains the pathway's diverse roles in development and cell fate determination.