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Engineering the mouse genome by site-specific recombination
1Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP Collége de France BP 163, 67404, Illkirch Cedex, CU de Strasbourg, France. metzger@igbmc.u-strasbg.fr
Current Opinion in Biotechnology
|October 6, 1999
Abstract:
Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.