Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methods for X-ray diffraction analysis of macromolecular structures.

J C Beauchamp1, N W Isaacs

  • 1Department of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.

Current Opinion in Chemical Biology
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Shoulder Presentation.

The Southern medical record·2022
Same author

Case of Tænia Solium Similating Pleuritis.

Atlanta medical and surgical journal·2022
Same author

Studies on the light-harvesting complexes from the thermotolerant purple bacterium Rhodopseudomonas cryptolactis.

Photosynthesis research·2013
Same author

The purple bacterial photosynthetic unit.

Photosynthesis research·2013
Same author

Structural factors which control the position of the Q(y) absorption band of bacteriochlorophyll a in purple bacterial antenna complexes.

Photosynthesis research·2005
Same author

1.2 Angstroms crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold.

FEBS letters·2005
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Protein crystallography now integrates molecular biology and advanced synchrotron sources. Improved phasing, data collection, and software enhance structure determination efficiency.

Area of Science:

  • Structural biology
  • Biophysics
  • Molecular genetics

Background:

  • Modern protein crystallography integrates molecular biology with traditional crystallographic methods.
  • Advancements in synchrotron sources are crucial for significant structure determinations.
  • Established phasing techniques find novel applications in complex structural studies.

Purpose of the Study:

  • To highlight the synergy between molecular biology and protein crystallography.
  • To underscore the impact of third-generation synchrotron sources.
  • To review advancements in phasing, data collection, and computational methods for protein structure determination.

Main Methods:

  • Utilizing third-generation synchrotron sources for data collection.
  • Applying established phasing techniques in novel ways.

Related Experiment Videos

  • Employing advanced data processing and computational analysis.

    • Main Results:

    • Biologically significant protein structures have been determined through integrated approaches.
    • New synchrotron sources facilitate breakthroughs in structural biology.
    • Improvements in phasing, data processing, and software have increased the effectiveness of structure determination.

    Conclusions:

    • The integration of molecular biology is essential for contemporary protein crystallography.
    • Third-generation synchrotron sources are vital for advancing the field.
    • Continuous improvements in methodology and computation enhance the efficiency and scope of protein structure determination.