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Structure and mechanism of ATP-dependent proteases
M Schmidt1, A N Lupas, D Finley
1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA.
Current Opinion in Chemical Biology
|October 6, 1999
Abstract:
A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.