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Recent developments in macrolides and ketolides.

D T Chu1

  • 1Discovery Research Kosan Biosciences, Inc. 3832 Bay Center Place, Hayward, CA 94545, USA. chu@kosan.com.

Current Opinion in Microbiology
|October 6, 1999
PubMed
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Bacterial resistance to macrolide antibiotics is rising. Novel macrolides and ketolides show promise against resistant strains, and macrolides may offer non-antibiotic therapeutic benefits.

Area of Science:

  • Microbiology
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Increasing bacterial resistance to macrolide antibiotics, especially in Gram-positive bacteria, poses a significant clinical challenge.
  • Macrolide antibiotics are crucial for treating various bacterial infections.

Purpose of the Study:

  • To investigate the efficacy of novel macrolide derivatives against resistant bacterial strains.
  • To explore potential non-antibacterial applications of macrolides.

Main Methods:

  • Synthesis and evaluation of novel macrolides with C-4" carbamate functional groups.
  • Assessment of ketolides (3-keto macrolide derivatives) against macrolide-resistant bacteria.
  • Investigation of macrolide effects on cytokine production and neutrophil-epithelial cell interactions.

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Main Results:

  • Novel macrolides and ketolides demonstrate activity against macrolide-resistant bacterial strains.
  • Macrolides exhibit potential non-antibacterial activities, including modulation of inflammatory responses and cellular transport.

Conclusions:

  • Novel macrolide structures and ketolides represent promising strategies to combat macrolide resistance.
  • Macrolides possess multifaceted biological activities beyond antibacterial effects, suggesting broader therapeutic potential.