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Related Experiment Videos

Codon usage and lateral gene transfer in Bacillus subtilis.

I Moszer1, E P Rocha, A Danchin

  • 1Unité de Régulation de l'Expression Génétique Institut Pasteur 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France.

Current Opinion in Microbiology
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

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Bacillus subtilis exhibits distinct gene classes based on codon preference, suggesting significant lateral gene transfer. Researchers are beginning to understand the selection pressures influencing this codon bias in bacteria.

Area of Science:

  • Microbiology
  • Genomics
  • Molecular Biology

Background:

  • Bacillus subtilis displays varied codon usage across its genome.
  • Certain gene classes correlate with prophage or prophage-like elements.
  • This suggests a history of lateral gene transfer in Bacillus subtilis.

Purpose of the Study:

  • To investigate the codon preference patterns in Bacillus subtilis.
  • To explore the implications of codon bias for understanding gene transfer.
  • To elucidate the selection pressures acting on codon usage.

Main Methods:

  • Analysis of gene sequences and codon usage statistics.
  • Identification of gene classes based on codon preference.
  • Comparative genomics to assess gene origins.

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Main Results:

  • Three distinct gene classes with differing codon preferences were identified in Bacillus subtilis.
  • One gene class was strongly associated with prophage-like sequences.
  • Evidence points to systematic lateral gene transfer shaping the Bacillus subtilis genome.

Conclusions:

  • The codon bias in Bacillus subtilis is influenced by lateral gene transfer events.
  • Understanding codon preference provides insights into bacterial genome evolution.
  • Further research is needed to fully characterize the selection pressures involved.