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Updated: Aug 12, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
Aminoglycoside-modifying enzymes
1Antimicrobial Research Centre Department of Biochemistry McMaster University 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada. wrightge@fhs.mcmaster.ca.
Abstract:
Bacterial resistance to the aminoglycoside antibiotics is most frequently associated with the expression of modifying enzymes that can phosphorylate, adenylate or acetylate these compounds. The recent availability of representative crystal structures for all three classes of modifying enzymes has greatly expanded our knowledge of enzyme function, and has revealed unexpected and exciting connections to other families of enzymes. Furthermore, the complete genome sequences for several bacteria have revealed many potential aminoglycoside-resistance elements.
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