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Related Experiment Videos

Fringe: defining borders by regulating the notch pathway.

J Y Wu1, Y Rao

  • 1Departments of Pediatrics, and Molecular Biology and Pharmacology Box 8116 Washington University School of Medicine, St Louis, Missouri, 63110, USA. jwu@molecool.wustl.edu

Current Opinion in Neurobiology
|October 6, 1999
PubMed
Summary

Fringe genes are crucial regulators of the Notch pathway, impacting cell-cell interactions in development. Their precise mechanisms in vertebrate neural tube and eye development require further investigation.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Notch pathway is essential for cell-cell communication during development.
  • Fringe genes encode proteins that modulate Notch signaling.
  • Fringe genes have established roles in Drosophila and vertebrate development.

Purpose of the Study:

  • To summarize the known functions of fringe genes in developmental processes.
  • To highlight the current understanding and gaps in knowledge regarding fringe gene roles in vertebrate neural tube and eye development.
  • To underscore the need for further research into the molecular mechanisms of Fringe protein function.

Main Methods:

  • Review of existing genetic and molecular studies on fringe genes and the Notch pathway.

Related Experiment Videos

  • Comparative analysis of fringe gene functions across different species (Drosophila and vertebrates).

    • Main Results:

    • Fringe genes are critical for establishing borders in Drosophila wing discs and eyes.
    • In vertebrates, fringe genes are involved in limb bud and somitic border formation.
    • The specific roles of fringe genes in vertebrate neural tube and eye development remain largely uncharacterized and may not be evolutionarily conserved.

    Conclusions:

    • Fringe proteins are key modulators of Notch signaling, influencing diverse developmental events.
    • Further research is needed to elucidate the mechanisms by which Fringe proteins regulate Notch pathway activation by different ligands.
    • Understanding Fringe function is critical for comprehending developmental patterning and cell-cell interactions.