Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sonic hedgehog opposes epithelial cell cycle arrest.

H Fan1, P A Khavari

  • 1VA Palo Alto Health Care System, Palo Alto, California 94304, USA.

The Journal of Cell Biology
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[STAT1 gain-of-function mutation leading to disseminated <i>Talaromyces marneffei</i> infection combined with hemophagocytic syndrome: a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
Same author

[Clinical characteristics and genetic spectrum of adults with primary ciliary dyskinesia].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
Same author

[Clinical cure and safe drug withdrawal in chronic hepatitis B].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2025
Same author

[Study on the current situation and influencing factors of uncivilized behavior in workplace encountered by nurses in Xianyang City].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.

Physiological research·2024
Same author

[Epidemiological and etiological characteristics of herpes pharyngitis in 3 prefectures in Jiangsu Province].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2024

Sonic hedgehog (Shh) pathway activation drives basal cell carcinoma (BCC) by preventing normal epithelial cell cycle arrest. Shh signaling disrupts the balance between cell proliferation and growth arrest, promoting neoplasia.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Oncology

Background:

  • Stratified epithelium maintains a balance between cell proliferation and cell cycle arrest.
  • Basal cell carcinoma (BCC) is characterized by a disruption of this balance.
  • Sonic hedgehog (Shh) pathway activation is implicated in BCC development, but the underlying mechanisms are unclear.

Purpose of the Study:

  • To investigate how Sonic hedgehog (Shh) pathway activation induces basal cell carcinoma (BCC).
  • To elucidate the molecular mechanisms by which Shh signaling disrupts normal epithelial cell cycle regulation.

Main Methods:

  • In vivo studies of Shh-expressing cells in the epidermis.
  • Analysis of cell cycle progression (S and G2/M phases) under Shh signaling.
  • Investigation of calcium-induced differentiation and replicative capacity.

Related Experiment Videos

  • Assessment of p21(CIP1/WAF1) expression and its effect on growth arrest.

    • Main Results:

    • Shh-induced epidermal hyperplasia involves sustained proliferation of suprabasal cells.
    • Shh-expressing cells fail to arrest in S and G2/M phases during differentiation.
    • These cells also resist replicative senescence.
    • Shh signaling actively inhibits p21(CIP1/WAF1)-mediated growth arrest.

    Conclusions:

    • Sonic hedgehog (Shh) pathway activation promotes neoplasia by overriding normal epithelial cell cycle arrest mechanisms.
    • Shh signaling disrupts the balance of proliferation and growth arrest, contributing to basal cell carcinoma (BCC) development.