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Updated: Jul 21, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
Mild hypophosphatasia mimicking severe osteogenesis imperfecta in utero: bent but not broken
R M Pauli1, P Modaff, S L Sipes
1Department of Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Abstract:
We describe a fifth instance of hypophosphatasia presenting with prenatal findings suggestive of a very severe bone dysplasia but with a subsequently benign course. Spontaneous improvement of long-bone angulation began prenatally. The postnatal course has been encouraging. This sixth clinical form of hypophosphatasia, which we suggest should be called the benign prenatal form of hypophosphatasia, should be added to the differential diagnostic possibilities considered when angulation or bowing of long bones is discovered prenatally.
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