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CD30 positive (non-anaplastic) peripheral T-cell lymphoma of the thyroid gland
F Forconi1, M Bocchia, S Marconcini
1Cattedra e Divisione di Ematologia, Ospedale Sclavo, via Tufi 1, 53100 Siena, Italy. forconif@unisi.it
Abstract:
Primary non-Hodgkin's lymphoma of the thyroid gland are infrequent tumors. They almost exclusively derive from B cells of mucosa-associated lymphatic tissue and only a very small minority of them is represented by T cell lymphomas. CD30 molecule, other than in Hodgkin's and Redd-Sternberg' cells, is strictly associated with anaplastic large cell lymphoma and ALK lymphomas, the latter being identified by the monoclonal antibody ALK1. We report a case of CD30-positive non-anaplastic (ALK1-negative) peripheral T cell lymphoma of the thyroid gland and speculate on aspects concerning diagnosis and the morphologic and immunohistochemical findings.