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Related Experiment Videos

Amphetamine disrupts P50 suppression in normal subjects.

G A Light1, D Malaspina, M A Geyer

  • 1Department of Psychiatry, University of California, San Diego, La Jolla 92093-0804, USA.

Biological Psychiatry
|October 6, 1999
PubMed
Summary

Amphetamine disrupted sensory gating, measured by P50 suppression, in healthy individuals. This finding suggests monoaminergic pathways may underlie P50 deficits observed in schizophrenia patients.

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Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • P50 suppression, a measure of sensory gating, is reduced in schizophrenia.
  • Rodent models show neural gating is modulated by monoaminergic tone.

Purpose of the Study:

  • To investigate if a monoaminergic agonist (amphetamine) causes P50 suppression deficits in healthy subjects.
  • To explore the role of monoamines in P50 gating.

Main Methods:

  • 11 healthy subjects underwent P50 event-related potential recordings.
  • Recordings were taken at baseline and after oral administration of dextroamphetamine or placebo.

Main Results:

  • Amphetamine significantly disrupted P50 suppression compared to baseline (p < .01).
  • A significant disruption of P50 suppression was observed in the amphetamine condition versus placebo (p < .01).

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Conclusions:

  • Amphetamine induces P50 suppression deficits in normal subjects.
  • These findings suggest monoaminergic alterations may contribute to P50 deficits in schizophrenia pathophysiology.