Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparing pupil function with visual function in patients with Leber's hereditary optic neuropathy.

F D Bremner1, J Shallo-Hoffmann, P Riordan-Eva

  • 1Department of Neuro-Ophthalmology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Investigative Ophthalmology & Visual Science
|October 6, 1999
PubMed
Summary

Pupil and visual function are impaired in Leber's hereditary optic neuropathy (LHON). However, pupil afferent fibers show relative sparing compared to visual function deficits in LHON patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sigmoid Sinus Diverticulum, Dehiscence, and Venous Sinus Stenosis: Potential Causes of Pulsatile Tinnitus in Patients with Idiopathic Intracranial Hypertension?

AJNR. American journal of neuroradiology·2017
Same author

Direct ophthalmoscopy should be taught to undergraduate medical students.

Eye (London, England)·2015
Same author

Brentuximab vedotin does not cause clinically relevant QTc interval prolongation in patients with CD30-positive hematologic malignancies.

Cancer chemotherapy and pharmacology·2013
Same author

Subacute peripheral and optic neuropathy syndrome with no evidence of a toxic or nutritional cause.

Clinical neurology and neurosurgery·2013
Same author

Hypoglycaemia-induced changes in regional brain volume and memory function.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

The association between body mass index and musculoskeletal foot disorders: a systematic review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2012

Area of Science:

  • Neuro-ophthalmology
  • Optic Neuropathies

Background:

  • Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease.
  • LHON primarily affects the optic nerve, leading to vision loss.

Purpose of the Study:

  • To compare pupil function with visual function in LHON patients.
  • To assess the relative impact of LHON on visual versus pupil pathways.

Main Methods:

  • Visual function assessed via automated static perimetry.
  • Pupil function measured by light stimulus response in the visual field.
  • Pupil afferent defect quantified by comparing stimulus intensity and pupil response size.

Main Results:

  • LHON patients showed significantly reduced pupil responses and raised perceptual thresholds.

Related Experiment Videos

  • Unperceived stimuli were more likely to elicit pupil responses in LHON patients.
  • Visual deficits were quantitatively larger than pupil deficits in LHON patients.

    • Conclusions:

    • Both visual and pupil functions are demonstrably abnormal in LHON.
    • Pupil afferent fibers appear relatively spared compared to visual pathways in LHON.