Related Experiment Videos
3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis
1Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Bioorganic & Medicinal Chemistry Letters
|October 6, 1999
Abstract:
Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities.