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Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonylpiperidin-1-yl)alkanes as potent antiarrhythmic agents
R C Tripathi1, S K Pandey, K Kar
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Bioorganic & Medicinal Chemistry Letters
|October 6, 1999
Abstract:
Synthesis and SAR studies of the title compounds have resulted in the identification of structural and physicochemical parameter (Vw) contributing for antiarrhythmic activity. Among the two most promising compounds 3a & 3b, the 3a has shown antiarrhythmic activity comparable to quinidine.