Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. jszhang@mail.shcnc.ac.cn
Bioorganic & Medicinal Chemistry Letters
|October 6, 1999
Abstract:
A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.
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