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Nutritional deficiencies in recurrent aphthae.

D Wray, M M Ferguson, W A Hutcheon

    Journal of Oral Pathology
    |January 1, 1978
    PubMed
    Summary
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    Nutritional deficiencies, including iron, folate, and vitamin B12, affect 14.2% of patients with recurrent aphthae. Full blood screening is recommended for these patients, as corrective therapy shows promising results.

    Area of Science:

    • Hematology
    • Nutritional Science
    • Oral Medicine

    Background:

    • Recurrent aphthae are common oral lesions.
    • Nutritional deficiencies can impact oral health.

    Purpose of the Study:

    • To investigate the prevalence of iron, folate, and vitamin B12 deficiencies in patients with recurrent aphthae.
    • To assess the efficacy of corrective therapy for identified deficiencies.

    Main Methods:

    • Screening of 330 patients with recurrent aphthae for nutritional deficiencies.
    • Peripheral blood analysis including hemoglobin, absolute values, and blood film examination.
    • Clinical examination for associated symptoms like glossitis and angular cheilitis.

    Main Results:

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  • 14.2% of patients (47/330) had deficiencies: 23 iron, 7 folate, 6 vitamin B12, and 11 combined.
  • Peripheral blood screening identified vitamin B12 deficiency but only a proportion of iron/folate deficiencies.
  • 33 patients with deficiencies showed positive response to therapy: 23 complete remission, 11 improved.

    • Conclusions:

    • Nutritional deficiencies are prevalent in recurrent aphthae patients.
    • Full hematological screening is warranted for recurrent aphthae.
    • Corrective therapy for deficiencies leads to significant improvement in oral ulcers.