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Systemic sclerosis: new insights in autoimmunity
S E Kaal1, F H van Den Hoogen, E M de Jong
1Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Abstract:
The strong female predilection of systemic sclerosis, especially in women after their childbearing years, and the clinical and histopathological similarities with chronic graft-versus-host disease make systemic sclerosis an interesting subject of debate. Recent studies concerning the pathogenesis of this disease demonstrated the persistence of fetal cells in the maternal circulation in a majority of female patients. How or whether microchimerism is involved in the pathogenesis of systemic sclerosis remains to be elucidated. The present paper reviews the recent findings on the subject.
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