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Time course of the effects of temocapril on cardiovascular structure and function in patients with essential

M Takata1, H Ueno, T Hirai

  • 1The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

Journal of Cardiovascular Pharmacology
|October 8, 1999
PubMed

Insights

Angiotensin-converting enzyme (ACE) inhibition with temocapril gradually reversed structural changes in hypertensive patients' left ventricles and arterioles over 12 months. However, large artery stiffness remained unaffected by this ACE inhibition therapy.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Essential hypertension is associated with cardiovascular structural changes.
  • Angiotensin-converting enzyme (ACE) inhibitors are a common treatment for hypertension.
  • Understanding the time course of structural changes during ACE inhibition is crucial.

Purpose of the Study:

  • To investigate the time course of cardiovascular structural changes in essential hypertension patients treated with an ACE inhibitor.
  • To assess the impact of temocapril on left ventricular structure, forearm vascular resistance, and carotid artery stiffness.

Main Methods:

  • A 12-month study involving 15 essential hypertensive subjects.
  • Measurements included left ventricular structure, forearm minimal vascular resistance, and carotid artery stiffness beta.
  • Temocapril treatment was administered, with assessments during a placebo period and at 2, 6, and 12 months.

Main Results:

  • Blood pressure decreased within 2 weeks and remained controlled for 12 months.
  • Left ventricular mass index significantly decreased after 2 months and normalized by 12 months.
  • Forearm minimal vascular resistance gradually decreased over 12 months.
  • Carotid artery stiffness beta showed no significant alteration during the 1-year treatment period.

Conclusions:

  • Temocapril treatment led to gradual regression of left ventricular and arteriolar structural changes in hypertensive patients.
  • Large artery structure, as indicated by carotid artery stiffness, was not affected by 1-year ACE inhibition.
  • ACE inhibition demonstrates progressive reversal of specific cardiovascular structural abnormalities in hypertension.

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