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Behavioral effects of chronic phencyclidine in monkeys
G S Linn1, R T O'Keeffe, C E Schroeder
1The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Neuroreport
|October 8, 1999
Summary
Chronic phencyclidine (PCP) administration in monkeys altered behaviors, differing from acute effects. This provides a new primate model for developing antipsychotic drugs targeting schizophrenia-like symptoms.
Area of Science:
- Neuroscience
- Pharmacology
- Primate Behavior
Background:
- Phencyclidine (PCP) and ketamine, NMDA receptor antagonists, induce psychosis resembling schizophrenia.
- Current medications struggle to reverse these drug-induced psychotic symptoms.
Purpose of the Study:
- To investigate the chronic behavioral effects of phencyclidine (PCP) in a primate model.
- To establish a relevant animal model for developing novel antipsychotic medications.
Main Methods:
- Six socially-housed Cebus apella monkeys received continuous PCP administration.
- Behavioral changes, including locomotion and social interactions, were systematically monitored.
Main Results:
- Chronic PCP decreased stereotyped locomotion (pacing) and increased scanning behavior.
- Lower doses reduced self/environment-directed actions and goal-directed locomotion, while increasing affiliative behavior.
- Four monkeys experienced extreme motor and physiological reactions to stress.
Conclusions:
- Chronic PCP administration in primates yields distinct behavioral effects compared to acute exposure.
- This primate model offers a valuable system for evaluating new antipsychotic drug candidates.
