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Related Experiment Videos

Cellular Functions of the Plasma Membrane Estrogen Receptor.

Levin1

  • 1aDivision of Endocrinology, Veterans Affairs Medical Center, Long Beach, CA 90822, USA.

Trends in Endocrinology and Metabolism: TEM
|October 8, 1999
PubMed
Summary
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Researchers have gathered evidence for an estrogen receptor (ER) on the cell membrane, which rapidly responds to 17beta-estradiol (E2). This membrane ER mediates nongenomic actions, though it remains unisolated.

Area of Science:

  • Cellular biology
  • Endocrinology
  • Molecular signaling

Background:

  • Decades of research suggest an estrogen receptor (ER) exists on the plasma membrane.
  • Initial reports indicated a membrane protein binding 17beta-estradiol (E2) and initiating rapid cellular responses.
  • These membrane-initiated signals are crucial for understanding estrogen's diverse effects.

Purpose of the Study:

  • To review the evidence supporting the existence of a plasma membrane estrogen receptor.
  • To highlight the role of this receptor in mediating rapid, nongenomic effects of estrogen.
  • To discuss the implications of a membrane-bound ER in cellular signaling pathways.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of data from multiple independent laboratories.

Related Experiment Videos

  • Synthesis of evidence regarding signal transduction events initiated at the cell membrane.

    • Main Results:

    • Consistent data from numerous labs support the presence of an ER on the cell surface.
    • Evidence suggests this membrane receptor binds 17beta-estradiol (E2) and triggers rapid signal transduction.
    • Recent studies confirm that nongenomic estrogen actions are mediated by this plasma membrane ER.

    Conclusions:

    • The existence of a functional plasma membrane estrogen receptor is strongly supported by accumulated evidence.
    • This receptor plays a key role in mediating rapid, nongenomic cellular responses to estrogen.
    • Further research is needed to isolate and fully characterize this elusive membrane receptor.