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Automation of functional assays by flow injection fluorescence microscopy
L D Scampavia1, P S Hodder, I Lähdesmäki
1Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA. scamp@u.washington.edu
Trends in Biotechnology
|October 8, 1999
Abstract:
Bead-injection spectroscopy is a novel technique that uses immobilized eukaryotic cells on microbeads as a renewable biosensor for fluorescence microscopy. The use of a flow injection instrument allows fast functional assays that generate full kinetic characterization of a drug. Because the cell population is automatically replaced for each assay, variability is minimized, thus allowing greater accuracy.