Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peroxisomes: simple in function but complex in maintenance.

H F Tabak1, I Braakman, B Distel

  • 1Dept of Biochemistry, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands. h.f.tabak@amc.uva.nl

Trends in Cell Biology
|October 8, 1999
PubMed
Summary

Peroxisomes are vital cell organelles. Genetic studies reveal PEX genes are crucial for peroxisome maintenance, and mutations cause severe human diseases, highlighting their importance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The gene for the small ribosomal RNA on yeast mitochondrial DNA: Physical map, direction of transcription and absence of an intervening sequence.

Current genetics·2013
Same author

Analysis of disulfide bond formation.

Current protocols in protein science·2008
Same author

Formation of peroxisomes: present and past.

Biochimica et biophysica acta·2006
Same author

Synthesis and quality control of viral membrane proteins.

Current topics in microbiology and immunology·2004
Same author

Low-density lipoprotein receptor structure and folding.

Cellular and molecular life sciences : CMLS·2004
Same author

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.

The Journal of cell biology·2001

Area of Science:

  • Cell Biology
  • Genetics
  • Human Disease

Background:

  • Peroxisomes are essential cellular organelles involved in various metabolic pathways.
  • Dysfunction or loss of peroxisomes leads to severe human diseases.
  • Genetic studies in yeast have identified key genes (PEX genes) regulating peroxisome biogenesis.

Purpose of the Study:

  • To review recent advancements in peroxisome research.
  • To elucidate the role of PEX genes in peroxisome maintenance.
  • To highlight the genetic basis of human peroxisomal disorders.

Main Methods:

  • Review of current scientific literature on peroxisome biology.
  • Analysis of genetic studies in yeast models.
  • Correlation of PEX gene mutations with human diseases.

Related Experiment Videos

Main Results:

  • PEX genes are indispensable for the formation and integrity of peroxisomes.
  • Mutations in PEX genes are a primary cause of human peroxisomal diseases.
  • Peroxisomes exhibit unique protein import mechanisms, such as importing folded proteins.

Conclusions:

  • Peroxisome dysfunction results in serious human health conditions.
  • Understanding PEX genes is critical for diagnosing and potentially treating peroxisomal disorders.
  • Further research is needed to unravel the remaining mysteries of peroxisome function and maintenance.