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Erythroderma in Thai patients
V Leenutaphong1, K Kulthanan, C Pohboon
1Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Summary
Erythroderma, a widespread skin condition, is often caused by drug reactions or existing skin diseases. Prompt withdrawal of the offending drug typically leads to good outcomes in drug-induced cases.
Area of Science:
- Dermatology
- Clinical Medicine
Background:
- Erythroderma is a severe dermatological condition with diverse etiologies.
- Understanding its incidence, causes, and clinicopathological features is crucial for effective management.
Purpose of the Study:
- To determine the incidence, causes, and clinicopathological characteristics of erythroderma.
- To investigate the correlation between clinicopathological findings and the etiology of erythroderma.
Main Methods:
- Retrospective review of clinical, laboratory, and biopsy data from 49 patients diagnosed with erythroderma over a 10-year period (1985-1994).
Main Results:
- The most common causes of erythroderma were drug reactions (38.77%) and preexisting dermatoses (26.5%).
- Drug-induced erythroderma presented with acute onset and favorable prognosis upon drug withdrawal, often associated with hepatomegaly and abnormal liver function.
- Cases linked to preexisting dermatoses frequently showed nail involvement. Clinicopathological findings were generally nonspecific, offering limited etiological insight.
Conclusions:
- Drug reactions and preexisting dermatoses are primary causes of erythroderma.
- Clinicopathological correlation offers minimal etiological information in erythroderma.
- Drug-induced erythroderma has a good prognosis with prompt intervention.