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Knock-out mouse models used to study neurobiological systems
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA.
Critical Reviews in Neurobiology
|October 8, 1999
Summary
Knock-out mice are increasingly used in neurobiology research to understand gene function in behavior and disease. This review covers their applications, advantages, and disadvantages in studying complex neurological processes.
Area of Science:
- Neurobiology
- Genetics
- Pharmacology
Background:
- Knock-out mouse models are a rapidly expanding tool in neurobiological research.
- They are utilized to investigate gene product roles in biochemical pathways, neuropharmacological responses, and complex behaviors.
Purpose of the Study:
- To discuss the advantages and disadvantages of using knock-out mice in neurobiology.
- To review the current state of knock-out technology.
- To examine the application of knock-out mice in elucidating neurotransmitter system functions and complex neurobiological problems.
Main Methods:
- Review of existing literature on knock-out mouse technology and applications.
- Analysis of case studies where knock-out mice have been used to study specific neurobiological questions.
Main Results:
- Knock-out mice provide valuable insights into gene function in neurobiology.
- Their application extends to understanding learning, memory, and drug abuse mechanisms.
- The technology offers a powerful, albeit complex, approach to neurobiological research.
Conclusions:
- Knock-out mice are essential for dissecting complex neurobiological mechanisms.
- Further development and application of this technology will advance our understanding of the brain.
- Careful consideration of advantages and disadvantages is crucial for effective utilization.