Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kawasaki disease.

J W Newburger1, J C Burns

  • 1Department of Cardiology, Children's Hospital, Boston, MA 02115, USA.

Vascular Medicine (London, England)
|October 8, 1999
PubMed
Summary
This summary is machine-generated.

Kawasaki disease, a vasculitis affecting children, can lead to coronary artery aneurysms. Early treatment with intravenous gamma globulin significantly reduces this risk, but long-term monitoring is crucial for all patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial.

Pediatric cardiology·2026
Same author

Kawasaki disease for the paediatric dermatologist: skin manifestations and new insights into the pathophysiology.

Clinical and experimental dermatology·2021
Same author

Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens.

Clinical and experimental immunology·2020
Same author

Association of Isolated Congenital Heart Disease with Fetal Brain Maturation.

AJNR. American journal of neuroradiology·2020
Same author

Cardiovascular imaging in children and adults following Kawasaki disease.

Insights into imaging·2015
Same author

2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs).

Journal of the American College of Cardiology·2015
Same journal

Images in Vascular Medicine: When coronary anatomy goes the wrong way-A diagnostic challenge.

Vascular medicine (London, England)·2026
Same journal

Home-based intravenous iloprost by portable elastomeric pump in chronic limb-threatening ischemia: A pilot study.

Vascular medicine (London, England)·2026
Same journal

Vascular Disease Patient Information Page: Renal denervation.

Vascular medicine (London, England)·2026
Same journal

Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.

Vascular medicine (London, England)·2026
Same journal

Generalizability of the CREST‑2 trial: A real‑world analysis.

Vascular medicine (London, England)·2026
Same journal

Downhill-walking exercise training in a patient with symptomatic peripheral artery disease: A case report.

Vascular medicine (London, England)·2026
See all related articles

Area of Science:

  • Pediatric Cardiology
  • Rheumatology
  • Immunology

Background:

  • Kawasaki disease is a primary cause of acquired heart disease in U.S. children.
  • It is an acute vasculitis of unknown origin, primarily affecting young children.
  • Coronary artery aneurysms affect 15-25% of affected children.

Purpose of the Study:

  • To review the impact of Kawasaki disease on pediatric coronary arteries.
  • To discuss the efficacy of intravenous gamma globulin in preventing coronary artery abnormalities.
  • To outline the long-term management and surveillance strategies for affected children.

Main Methods:

  • Review of existing literature on Kawasaki disease and its cardiovascular sequelae.
  • Analysis of treatment outcomes, particularly the role of intravenous gamma globulin.

Related Experiment Videos

  • Discussion of diagnostic and interventional approaches for coronary artery complications.

    • Main Results:

    • Intravenous gamma globulin treatment in the acute phase decreases the risk of coronary artery aneurysms by 3-5 times.
    • Half of aneurysmal segments show angiographic resolution but retain histologic and functional deficits.
    • Giant aneurysms (>8 mm) carry the worst prognosis due to thrombosis risk.

    Conclusions:

    • Early intravenous gamma globulin administration is critical for mitigating coronary artery damage in Kawasaki disease.
    • Ongoing surveillance, including stress tests and imaging, is essential for managing coronary artery disease.
    • Long-term follow-up is necessary to understand the natural history of Kawasaki disease and its vascular impact.