Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal growth despite GH, IGF-I and IGF-II deficiency.

E H Hathout1, D J Baylink, S Mohan

  • 1Loma Linda University Children's Hospital and School of Medicine and Jerry L Pettis VA Medical Center, Loma Linda, CA, USA.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|October 8, 1999
PubMed
Summary

This study presents a case of normal growth in a child with panhypopituitarism and a deficient growth hormone (GH)/insulin-like growth factor (IGF) axis, suggesting an unknown growth mechanism. Further research is needed to understand GH-independent growth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice.

Gene therapy·2015
Same author

Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice.

Bone·2007
Same author

Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice.

Calcified tissue international·2007
Same author

Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice.

Calcified tissue international·2006
Same author

High osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is associated with low apoptosis in C3H/HeJ osteoblasts.

Calcified tissue international·2006
Same author

Serum levels of insulin-like growth factor (IGF); IGF-binding proteins-3, -4, and -5; and their relationships to bone mineral density and the risk of vertebral fractures in postmenopausal women.

Calcified tissue international·2006

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Deficiency
  • Insulin-like Growth Factor Axis

Background:

  • Presents a rare case of a 6.5-year-old male with septo-optic dysplasia and panhypopituitarism, exhibiting normal linear growth despite a deficient growth hormone (GH) and insulin-like growth factor (IGF) axis.
  • Investigates the roles of various growth factors and binding proteins, including IGF-I, IGF-II, IGFBP-3, IGFBP-1, -2, -4, -5, and leptin, in a patient with GH deficiency.

Observation:

  • The patient displayed undetectable GH levels, elevated GH binding protein (GHBP), and low serum IGF-I, IGF-II, IGFBP-3, and IGFBP-5.
  • Serum IGF-II exhibited normal molecular size, indicating normal bioavailability.
  • Markedly elevated leptin levels were observed, but leptin did not stimulate osteoblast proliferation.

Findings:

Related Experiment Videos

  • Normal linear growth and osteoblast cell proliferation occurred despite the absence of significant GH, IGFs, insulin, or leptin-mediated activity.
  • Human osteosarcoma cell proliferation assays showed serum growth-promoting activity comparable to normal controls.
  • The study excludes IGF-II and leptin as mediators of GH-independent growth in this specific case.

    • Implications:

    • Suggests the existence of an unidentified growth factor or alternative mechanism responsible for normal growth in the absence of a functional GH/IGF axis.
    • Highlights the utility of osteoblast cell proliferation assays for assessing serum growth-promoting activity in complex growth disorders.
    • Underscores the incomplete understanding of the intricate mechanisms governing human growth, particularly in cases of GH-independent growth.