Related Experiment Video
Updated: Aug 10, 2026

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Published on: March 25, 2015
Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon alpha
M Foldvari1, M E Baca-Estrada, Z He
1College of Pharmacy and Nutrition, 110 Science Place, University of Saskatchewan, Saskatoon, SK, Canada S7N 5C9.
Abstract:
The dermal and transdermal delivery of protein pharmaceuticals faces enormous challenges, and at the same time has very significant potential for the non-invasive treatment of both localized and systemic diseases. In this article we review the various approaches used to enhance and control the delivery of protein therapeutic agents through the dermal barrier. We show results of the delivery of interferon (IFN) alpha, an antiviral agent used in the treatment of condylomata acuminata (genital warts), using lipid-based delivery systems (LBDS). In the general category of LBDS, we investigated the use of liposomes and fatty acylation as ways to increase IFNalpha delivery into human skin.
Related Concept Videos
Bioavailability Enhancement: Drug Permeability Enhancement
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Transdermal Drug Delivery Systems
Inhibitors of Viral Protein Synthesis

