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Driven polymer translocation through a narrow pore.

D K Lubensky1, D R Nelson

  • 1Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA. lubensky@cmt.harvard.edu

Biophysical Journal
|October 8, 1999
PubMed
Summary
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We studied polymer motion through nanopores, finding polymer length affects translocation times. Chemical composition and orientation significantly influence polymer speed in the pore.

Area of Science:

  • Biophysics
  • Polymer Physics
  • Nanotechnology

Background:

  • Experiments involve driving polynucleotides through protein pores using electric fields.
  • Understanding polymer dynamics in confined environments is crucial for nanotechnology and biophysics.

Purpose of the Study:

  • To investigate the diffusive motion of polymers through narrow channels with strong interactions.
  • To develop theoretical models for polymer translocation dynamics.
  • To explain experimental observations of translocation time distributions.

Main Methods:

  • Developing a coarse-grained description for translationally invariant regimes.
  • Introducing a microscopic model to capture chemical and orientational dependencies.
  • Analyzing the distribution of polymer passage times.

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Main Results:

  • Identified a regime of approximate translational invariance for specific polymer lengths.
  • Deduced general features of polymer translocation time distributions from the coarse-grained model.
  • The microscopic model shows polymer speed depends on chemical composition and orientation.

Conclusions:

  • Polymer translocation through nanopores is complex, influenced by polymer length, chemical properties, and orientation.
  • The developed models provide insights into experimental observations, including broader-than-expected translocation time distributions.
  • Further research is needed to fully explain the wide distribution of experimental translocation times.