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Frequency and determinants of postprocedural hemodynamic instability after carotid angioplasty and stenting
A I Qureshi1, A R Luft, M Sharma
1Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Insights
Hemodynamic instability is common after carotid angioplasty with stenting (CAS). Patients experiencing instability during the procedure face the highest risk of post-CAS complications, necessitating close monitoring.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Neurosurgery
Background:
- Hemodynamic instability, including hypotension, hypertension, and bradycardia, can occur acutely after carotid angioplasty and stent placement (CAS).
- Understanding the frequency and predictors of these events is crucial for patient management.
Purpose of the Study:
- To determine the frequency of hemodynamic instability following CAS.
- To identify demographic, clinical, intraprocedural, and angiographic factors associated with postprocedural hemodynamic events.
Main Methods:
- A retrospective review of 51 patients undergoing CAS for carotid artery stenosis was conducted.
- Hemodynamic parameters (hypotension, hypertension, bradycardia) were recorded in the acute postprocedural period.
- Logistic regression analysis was used to identify predictors of hemodynamic instability.
Main Results:
- Postprocedural hypotension occurred in 22.4%, hypertension in 38.8%, and bradycardia in 27.5% of patients.
- Intraprocedural hypotension and history of myocardial infarction predicted postprocedural hypotension.
- Intraprocedural hypertension and prior ipsilateral carotid endarterectomy predicted postprocedural hypertension.
- Intraprocedural hypotension and bradycardia predicted postprocedural bradycardia.
Conclusions:
- Postprocedural hemodynamic instability is frequent after CAS, underscoring the need for vigilant monitoring.
- Patients exhibiting hemodynamic instability during CAS are at significantly higher risk for postprocedural complications.
Background And Purpose:
Hemodynamic instability can occur acutely after carotid angioplasty and stent placement (CAS). We performed this study to determine the frequency of hemodynamic instability in a series of patients who underwent CAS and to analyze factors associated with development of postprocedural hemodynamic events.
Methods:
We reviewed medical records and angiograms in a series of 51 patients (mean age 68.3+/-8.9 years) who underwent CAS for symptomatic (n=29) or asymptomatic (n=22) carotid artery stenosis. Any episodes of hypotension (systolic blood pressure <90 mm Hg), hypertension (systolic blood pressure >160 mm Hg), or bradycardia (heart rate <60 bpm) that occurred in the acute postprocedural period were recorded. The effect of demographic, clinical, intraprocedural, and angiographic factors on subsequent development of hemodynamic instability was analyzed by logistic regression.
Results:
The frequency of postprocedural hemodynamic complications in our patient series was as follows: hypotension, 22.4%; hypertension, 38.8%; and bradycardia, 27.5%. Intraprocedural hypotension (odds ratio [OR] 14.6, P=0.024) and history of myocardial infarction (OR 14.1, P=0.04) independently predicted postprocedural hypotension. Postprocedural hypertension was predicted by intraprocedural hypertension (OR 7.6, P=0.01) and previous ipsilateral carotid endarterectomy (OR 7.6, P=0.02). Postprocedural bradycardia was associated with intraprocedural hypotension (OR 74, P=0.001) and intraprocedural bradycardia (OR 12, P=0.008). All events had resolved at the conclusion of the intensive care unit monitoring period (mean 25.7 hours, range 18 to 43 hours).
Conclusions:
Postprocedural hemodynamic instability is frequent after CAS and supports the need for monitoring in settings suited to expeditious management of cardiovascular emergencies. Patients who have evidence of hemodynamic instability during the procedure are at highest risk.