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New antimycobacterial saponin from Colubrina retusa
H N ElSohly1, S Danner, X C Li
1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, Thad Cochran Research Center, The University of Mississippi, University, Mississippi 38677, USA. helsohly@olemiss.edu
Journal of Natural Products
|October 9, 1999
Abstract:
A new jujubogenin saponin was isolated from the stems of Colubrina retusa and identified as jujubogenin 3-O-alpha-L-arabinofuranosyl (1-->2)-[3-O-(trans)-p-coumaroyl-beta-D-glucopyranosyl (1-->3)]-alpha-L-arabinopyranoside (4) on the basis of chemical and spectroscopic data. The antimycobacterial activity expressed as minimum inhibitory concentration (MIC) for compound 4 was 10 microg/mL.