Solitary plasmacytoma presenting as peripheral neuropathy: a case report

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A K Mankodi1, C V Rao, S M Katrak

  • 1Department of Neurology, Grant Medical College and J.J. Group of Hospitals, Mumbai, 400008, India.

Neurology India
|October 9, 1999
PubMed

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...