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Structure-function analysis of the feline herpesvirus virulence factors gE and gI
1Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands.
Veterinary Microbiology
|October 9, 1999
Abstract:
The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.