Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-dose discrimination training with midazolam: context determines generalization profile.

N A Ator1

  • 1Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

Pharmacology, Biochemistry, and Behavior
|October 9, 1999
PubMed
Summary

Training rats to discriminate high doses of midazolam resulted in greater differentiation among benzodiazepine site ligands. This suggests the training dose context, not just the dose, influences drug selectivity in behavioral discrimination tasks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior.

Translational psychiatry·2015
Same author

Statistical inference in behavior analysis: Environmental determinants?

The Behavior analyst·2012
Same author

Behavioral biology.

The Behavior analyst·2012
Same author

Behavioral and pharmacological variables affecting risky choice in rats.

Journal of the experimental analysis of behavior·2001
Same author

Drug discrimination: stimulus control during repeated testing in extinction.

Journal of the experimental analysis of behavior·2001
Same author

Zaleplon and triazolam: drug discrimination, plasma levels, and self-administration in baboons.

Drug and alcohol dependence·2000

Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Previous studies showed greater ligand differentiation at the benzodiazepine site using multiple midazolam doses for training.
  • It was hypothesized that training with a high midazolam dose (3.2 mg/kg) might enhance drug selectivity compared to lower doses.

Purpose of the Study:

  • To investigate if training rats to discriminate a high dose of midazolam (3.2 mg/kg) from a vehicle enhances selectivity among benzodiazepine site ligands.
  • To compare the results with previous studies using different midazolam training doses.

Main Methods:

  • Rats were trained to discriminate 3.2 mg/kg midazolam from no drug using a two-lever, food-maintained operant procedure.
  • A range of benzodiazepine site ligands were tested in this trained group.

Related Experiment Videos

Main Results:

  • Most tested drugs dose-dependently occasioned responding on the midazolam-appropriate lever, with varying potencies.
  • Greater differentiation among ligands was observed compared to previous studies using lower midazolam training doses.
  • Only triazolam occasioned high-dose midazolam-appropriate responding in prior work, suggesting context-dependent effects.

Conclusions:

  • The enhanced differentiation among ligands appears to be due to the training dose context rather than solely the high dose of midazolam.
  • Behavioral discrimination paradigms can be sensitive to the specific training dose regimen used, impacting observed drug selectivity.