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The novel-response procedure in humans.

B J Smith¹, W K Bickel

¹Departmant of Psychology, University of Vermont, Burlington 05401, USA.

Pharmacology, Biochemistry, and Behavior

|October 9, 1999

Summary

The novel-response drug discrimination procedure improves drug selectivity. This method uses instructions, not explicit training, to differentiate drug effects more precisely than standard two-response methods.

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Area of Science:

Pharmacology
Behavioral Neuroscience
Psychopharmacology

Background:

Standard two-response drug discrimination procedures can present interpretational challenges.
Three-choice procedures offer potential solutions to these limitations.
The novel-response procedure is a unique instructional approach within three-choice paradigms.

Purpose of the Study:

To assess the utility of the novel-response drug discrimination procedure.
To compare the novel-response procedure with standard two-response procedures.
To evaluate the impact on drug selectivity and the ability to distinguish between sedatives.

Main Methods:

Participants were trained on a standard two-response (drug vs. placebo) discrimination.
A novel-response alternative was introduced using instructions for a drug stimulus different from training drugs.
The study compared drug discrimination effects under both standard two-response and novel-response procedures using triazolam.

Main Results:

The novel-response procedure enhanced the selectivity of both placebo-appropriate and drug-appropriate responding.
This method allowed for finer distinctions among sedative drug effects compared to standard procedures.
Increased selectivity was observed in participants discriminating triazolam from placebo.

Conclusions:

The novel-response drug discrimination procedure is a valuable tool for increasing the precision of drug effect analysis.
Instructional control in the novel-response paradigm enhances the ability to differentiate between similar drug classes, such as sedatives.
This procedure offers an advantage over traditional two-response methods for detailed psychopharmacological research.

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