Related Experiment Videos
Discriminated taste aversion and context: a progress report
1MCP Hahnemann University, Institute of Addiction Disorders, Department of Psychiatry, Philadelphia, PA 19102-1192, USA.
Pharmacology, Biochemistry, and Behavior
|October 9, 1999
Summary
This study shows that environmental context and conditioning influence opiate-controlled behaviors. Drug discrimination using taste aversion is sensitive to morphine dose and context, revealing morphine
Area of Science:
- Behavioral neuroscience
- Psychopharmacology
- Respondent conditioning
Background:
- Understanding how environmental context influences drug-controlled behaviors is crucial.
- Opiate effects are modulated by conditioning and contextual cues.
Purpose of the Study:
- To investigate the interaction between environment, organism, and opiate effects.
- To apply drug discrimination to a respondent conditioning procedure (discriminated taste aversion, DTA).
Main Methods:
- Utilized discriminated taste aversion (DTA) as a respondent conditioning procedure.
- Assessed sensitivity to morphine dose and saccharin concentration.
- Conducted substitution tests with delta-9-tetrahydrocannabinol.
Main Results:
- DTA is a feasible method sensitive to morphine dose and saccharin concentration.
- Increasing LiCl dose (UCS magnitude) improved DTA control.
- Morphine alone can act as a discriminative stimulus, independent of saccharin context.
Conclusions:
- Environmental context and conditioning play significant roles in drug-controlled behaviors.
- Morphine's discriminative properties are not solely dependent on contextual elements like saccharin.
- This research contributes to the systematic analysis of drug-controlled behavior and context interaction.