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Related Experiment Videos

Discriminated taste aversion and context: a progress report.

T U Järbe1, R J Lamb

  • 1MCP Hahnemann University, Institute of Addiction Disorders, Department of Psychiatry, Philadelphia, PA 19102-1192, USA.

Pharmacology, Biochemistry, and Behavior
|October 9, 1999
PubMed
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This study shows that environmental context and conditioning influence opiate-controlled behaviors. Drug discrimination using taste aversion is sensitive to morphine dose and context, revealing morphine

Area of Science:

  • Behavioral neuroscience
  • Psychopharmacology
  • Respondent conditioning

Background:

  • Understanding how environmental context influences drug-controlled behaviors is crucial.
  • Opiate effects are modulated by conditioning and contextual cues.

Purpose of the Study:

  • To investigate the interaction between environment, organism, and opiate effects.
  • To apply drug discrimination to a respondent conditioning procedure (discriminated taste aversion, DTA).

Main Methods:

  • Utilized discriminated taste aversion (DTA) as a respondent conditioning procedure.
  • Assessed sensitivity to morphine dose and saccharin concentration.
  • Conducted substitution tests with delta-9-tetrahydrocannabinol.

Main Results:

Related Experiment Videos

  • DTA is a feasible method sensitive to morphine dose and saccharin concentration.
  • Increasing LiCl dose (UCS magnitude) improved DTA control.
  • Morphine alone can act as a discriminative stimulus, independent of saccharin context.

Conclusions:

  • Environmental context and conditioning play significant roles in drug-controlled behaviors.
  • Morphine's discriminative properties are not solely dependent on contextual elements like saccharin.
  • This research contributes to the systematic analysis of drug-controlled behavior and context interaction.